An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction
نویسندگان
چکیده
Chen Zhu1, Kaori Sakuishi1, Sheng Xiao1, Zhiyi Sun2, Sarah Zaghouani1, Guangxiang Gu1, Chao Wang1, Dewar J. Tan1, Chuan Wu1, Manu Rangachari1, Thomas Pertel1, Hyun-Tak Jin3, Rafi Ahmed3, Ana C. Anderson1, and Vijay K. Kuchroo1 1Evergrande Center for Immunologic Diseases, Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, Boston 02115, MA, USA
منابع مشابه
An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
The inhibitory receptor T-cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of the T-cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signalling pathways that drive Tim-3 expression. Here, we demonstrate that interleukin (IL)-27 induces nuclear factor, interleukin 3 regulated (NFIL3), which promotes p...
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